SCHOTT TOPPAC® sensitive

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Prefillable COC syringes for sensitive drugs

SCHOTT TOPPAC® sensitive syringes are designed to keep biologics and other sensitive drugs stable, reducing contaminations that could impact the drug stability such as E&L, free radicals, free silicone oil and sub-visual particles. Made from a break-resistant and lightweight COC material, TOPPAC® sensitive syringes offer excellent barrier properties, no ion or heavy metal release and low protein adsorption to increase drug shelf life.

A key advantage of these advanced glass-like syringes is the low material-impacted sterilization methods EtO- and steam sterilization, the use of newest and cleanest rubber formulations as well as a reactive siliconization process to reduce free silicone oil and sub-visual particles. 

 

Properties

  • Designed for the storage and delivery of biologics and other sensitive drugs. 
  • Reduces drug contamination for increased shelf life and patient safety.
  • Made using an advanced Cyclic Olefin Copolymer (COC) material, which is inert and stable for a broad range of solutions. 
  • Sterilized using Ethylene Oxide (EtO) to reduce free radicals and extractables. 
  • Manufactured using cross-linked silicone for lower free silicone and reduced silicone droplets. 
  • Tip cap and plunger made from steam-sterilized, pure rubber formulations.
Chemical Resistance

• The advanced COC material used in SCHOTT TOPPAC® sensitive syringes is inert and stable for a broad range of solutions. 
• COC material exhibits excellent barrier properties for water vapor and oxygen permeability, leading to longer drug shelf life.  
• No ion or metal release. 
• Made using pure elastomeric components for reduced particle load and chemical extractables. 
• COC material manufactured in accordance with EP, JP, and USP class VI (DMF 12132) standards. 
• Supported by extractable studies, as well as biocompatibility studies. 
 • Extremely low sub visual particle load: compliant with USP 789

• Syringe material made from inert COC material with no ion or heavy metal release and excellent barrier properties. 
• Made using pure elastomeric components for reduced particle load and chemical extractables. 
• Exhibits an extremely low sub visual particle load, compliant with the international standard USP 789. 
• Manufactured using cross-linked silicone for lower free silicone and reduced silicone droplets. 

Dimensions & Cosmetics

• SCHOTT TOPPAC® sensitive syringes are available in a range of volumes from 1-10 ml.
• The syringes are lightweight, with a glass-like appearance. 
• Injection molding of the syringe barrel allows for small tolerances and very little dead space. 
• Very low quantity of free silicone, which enables gliding forces to remain constant over time. 

Possible Applications
  • Biologics 
    Since SCHOTT TOPPAC® sensitive syringes offer high levels of stability and barrier properties, biologics and other sensitive drugs remain safe for longer, increasing safety and reducing costs. 
  • Ophthalmics
    Storing and administering medication to the eye requires syringes that can not only keep highly sensitive drugs stable, but deliver very low volume drugs accurately. SCHOTT TOPPAC® sensitive answers these challenges. 
  • WFI
    SCHOTT TOPPAC® sensitive syringes are ideal for water-for-injection (WFI) applications, since they offer excellent barrier properties for water vapor and oxygen permeability. 
Advantages

• SCHOTT TOPPAC® sensitive syringes are made from the highest quality COC material, which is inert and stable for a broad range of highly sensitive solutions. 
• Syringes are delivered in ready-to-use packages with volumes ranging from 1-10 ml. 
• SCHOTT provides a one-stop-shop for syringes and a broad range of compatible components. 
• SCHOTT TOPPAC® sensitive syringes have the highest quality standards, with extremely low sub visual particle load.
• SCHOTT has a proven track record in pharmaceutical packaging and is registered in more than 90 countries. 
• Our syringes are manufactured in accordance with EP, JP, and USP class VI (DMF 12132) standards. 
• Manufacturing process is validated and documented by the US FDA and China NMPA regulatory bodies.

Want to know more? Let's talk.

Whether you need more information, samples, a quote, or advice for a project, we would be delighted to talk to you.

Want to know more? Let's talk.

Whether you need more information, samples, a quote, or advice for a project, we would be delighted to talk to you.